THE
INTERNAL
SCAFFOLDING PROTEIN
The
coat-internal scaffolding
protein asymmetric unit as it
appears in the atomic structure of the viral procapsid. The viral coat
protein
is depicted in blue, the internal scaffolding protein in orange.
- Current Investigator: Emile Gordon
- Alumni Investigators: Min Chen, Dr. Asako Achiyama, Dr. April
Burch-Alden,
Chris Novak.
- Collaborator: Dr. Michael Rossmann's group (Purdue
University).
Clicking on the link belows will
retrieve a pdf of the manuscript.
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Chen,
M. Uchiyama, A., Fane, B. A. (2007) Eliminating the requirement of an
essential gene product in an already very small virus: scaffolding
protein B-free øX174, B-free. J. Mol Biol. 373: 308-14.
Novak, C. R. , Fane, B. A. (2004)The
functions of the N-terminus of the øX174 internal scaffolding
protein, a protein encoded in an overlapping reading frame, in a
two scaffolding protein system. J. Mol. Biol. 335:383-90.
Bernal, R. A., Hafenstein, S. , Olson, N. H.,
Bowman, V.D., Chipman, P.R., Baker, T. S., Fane, B. A, Rossmann, M. G.
(2003) Structural studies of bacteriophage alpha3 assembly. J.
Mol. Biol. 325: 11-24. PMID: 12473449.
Burch, A. D., Fane, B. A. (2000) Efficient
complementation by chimeric Microviridae internal scaffolding proteins
is a function of the COOH-terminus of the encoded protein. Virology
270: 286-290. PMID: 10792987.
Burch, A. D. , Ta, J., Fane, B. A. (1999)
Cross-functional analysis of the Microviridae Internal Scaffolding
protein. J. Mol. Biol. 286: 95-104. PMID: 9931252.
