At the 2001 FASEB Conference, The Calpain Family in Health and
Disease, a discussion was held concerning calpain nomenclature. The proposed
changes are summarized below. You
may download a copy of these tables in pdf format. If you have comments or
suggestions on the nomenclature of the calpains, please fill out our survey
form.
Table 1. Mammalian calpain family
Calpain
protein #
|
Calpain
gene
|
Other
Names
|
EF-hand
|
Tissue
Type
|
Species
|
Chromo-some
#
|
Genebank
Accession #
|
Calpain
1
|
capn1
|
µ-Calpain,
CAPN1
|
+
|
Ubiquitous
|
Human
|
11q13
|
X04366
|
Mouse
|
19
|
NM_007600
|
Rat
|
NA
|
NM_019152
|
Calpain
2
|
capn2
|
m-Calpain,
CAPN2
|
+
|
Ubiquitous
|
Human
|
1q41
|
NM_001748
|
Mouse
|
NA
|
NM_009794
|
Rat
|
NA
|
NM_017116
|
Calpain
3
|
capn3
|
nCL-1,
p94,
(Lp82,
Lp85
Rt88)
|
+
|
Skeletal
muscle,
lens,
retina
|
Human
|
15q15.1
|
X85030
|
Mouse
|
2
|
NM_007601
AF091998
|
Rat
|
NA
|
NM_017117
U96367
|
Calpain 5
|
capn5
|
htra3
nCL-3
|
-
|
Ubiquitous
(High in colon, small intestine and testis)
|
Human
|
11q14
|
NM_004055
|
Mouse
|
7
|
NM_007602
|
Rat
|
NA
|
NA
|
Calpain
6
|
capn6
|
CAPNX,
Calpamodulin
|
-
|
Placenta?
|
Human
|
Xq28
|
NM_014289
|
Mouse
|
X
|
NM_007603
|
Rat
|
NA
|
AF067793
|
Calpain
7
|
capn7
|
palBH
|
-
|
Ubiquitous
|
Human
|
3p24-p25
|
AB028639
|
Mouse
|
NA
|
NM_009796
|
Rat
|
NA
|
NA
|
Calpain
8
|
capn8
|
nCL-2
|
+
|
Stomach
mucosa
|
Human
Mouse
Rat
|
1q41
NA
NA
|
AA_043093^
|
NA
|
D14479-D14480
|
Calpain
9
|
capn9
|
nCL-4
|
+
|
Digestive
track
|
Human
|
1q42
|
NM_006615
|
Mouse
|
NA
|
U89513
|
Rat
|
NA
|
U89514
|
Calpain
10
|
capn10
|
CAPN10,
CaPn8
|
-
|
Ubiquitous
|
Human
|
2q37.3
|
AF089088,
AF089090
-96
|
Mouse
|
NA
|
NM_011796
AF089089
|
Rat
|
NA
|
AF227909
|
Calpain
11
|
capn11
|
CAPN11
|
+
|
Testis
|
Human
|
6p12
|
AJ242832
|
Mouse
|
NA
|
NA
|
Rat
|
NA
|
NA
|
Calpain
12
|
capn12
|
CAPN12
|
+
|
Ubiquitous
(High
in hair follicle)
|
Human
|
NA
|
NA
|
Mouse
|
19q13
|
AJ289241
|
Rat
|
NA
|
NA
|
Calpain
13
|
capn13
|
CAPN13
|
+
|
Testis/Lung
|
Human
|
2p22.2-p22.3
|
(AC068689)
^
|
Calpain
14
|
capn14
|
CAPN14
|
_
|
Ubiquitous
|
Human
|
2p22.2-p22.3
|
(AC015980)
^
|
Calpain
15
|
capn15
|
Sol
H
|
-
|
Ubiquitous
|
Human
|
16p13.3
|
U85647
|
Mouse
|
17A3.3
|
NM015830
|
Rat
|
NA
|
NA
|
Calpain
Small Subunit 1
|
capn-s1
or
cpns1
|
CAPN4
|
+
|
Ubiquitous
|
Human
|
19q13.1
|
NM_001749
|
Mouse
|
NA
|
NM_009795
|
Rat
|
NA
|
RNU10861
|
Calpain
Small Subunit 2
|
capn-s2
or
cpns2
|
|
+
|
NA
|
Human
|
16
|
AC026802
|
Mouse
|
NA
|
AK009171
|
Rat
|
NA
|
NA
|
*Proposed
name
# Old name
^
Partial sequences only
NA = Not available
Note: There will be no calpain 4
µ-Calpain =protein
heterodimer of Calpain 1 and one small subunit
m-Calpain
=protein heterodimer of Calpain 2 protein and one small subunit
Table 2. Calpain family in Drosophila
Drosophila Calpain protein
|
gene
|
Other names
|
Calpain A
|
CalpA
|
Dm-Calpain A
|
Calpain B
|
CalpB
|
Dm-Calpain B
|
Calpain C
|
CalpC
|
CCG3692
|
Calpain D
|
CalpD
|
SOL
|
Table 3.Nematode C. elegans calpain
There are 12 putative calpains with 7 identified in C. elegans.
C. elegans Calpain protein
|
gene
|
Other names
|
Calpain 1
|
capn1
|
CE00518/ p71
|
Calpain 2
|
capn2
|
CE01070/ p92
|
Calpain 3
|
capn3
|
CE24374/ p72.8
|
Calpain 4
|
capn4
|
CE25258/ p76
|
Calpain 5
|
capn5
|
CE16260/ TRA-3
|
Calpain 6
|
capn6
|
CE25611/ p90
|
Calpain 7
|
capn7
|
CE25612/ p86
|
|