Ph.D. in Ecology and Evolution, Stony Brook University 2003
B.S. in Biological Sciences, University of California Irvine 1996
Our lab investigates how the ecology of a species shapes patterns of variation (from genes to genomes), how populations adapt to environmental shifts and the implication of ecological adaptation in the process of speciation. Our research revolves around these fundamental aspects of evolution. Our work focuses on: (i) the study of the genetical basis of adaptation; (ii) speciation genetics/genomics and the evolution of reproductive incompatibilities; (iii) the effects of ecological adaptation in behavioral evolution and its effects on reproductive isolation; (iv) analysis of genome evolution via the sequencing and assembly for several cactophilic Drosophila species; (v) examining the role of gene expression changes in evolution; (vi) the relationship between molecular, expression and life history variation and evolution; (vii) using new genome editing techniques, CRISPR-Cas9, assess the functional consequence of variants in an ecological context. We mostly focus on a group of cactophilic Drosophila that inhabit the deserts of North America. These Drosophila species are an excellent system to study given that their ecology is well understood and the fact that we can perform many genetic, genomic, manipulative and life history experiments.
Bono, J. M., Killian, E. O., Matzkin, L. M. (2015). Connecting genotypes, phenotypes, and fitness: Harnessing the power of CRISPR/Cas9 genome editing. Molecular Ecology. 24:3810-3822.
Bono, J. M.*, Matzkin, L. M*, Hoang, K., and Brandsmeier, L. (2015). Molecular evolution of genes involved in post-mating pre-zygotic isolation in cactophilic
Matzkin, L. M. (2014). Ecological genomics of host shifts in Drosophila mojavensis. Advances in Experimental Medicine and Biology. 781:233-247.
Matzkin, L. M. (2012). Population transcriptomics of cactus host shifts in Drosophila mojavensis. Molecular Ecology. 21:2428-2439.
Bono, J. M.*, Matzkin, L. M.*, Kelleher, E. S., Markow, T. A. (2011). Postmating transcriptional changes in reproductive tracts of con- and heterospecifically-mated Drosophila mojavensis females. Proceedings of the National Academy of Sciences. (*Authors contributed equally). 108:7878-7883.
Matzkin, L. M., and Markow, T. A. (2009). Transcriptional regulation of metabolism associated with the increased desiccation resistance of the cactophilic Drosophila mojavensis. Genetics. 182:1279-1288.
Schaeffer, S. W., Bhutkar, A., McAllister, B. F., Matsuda, M., Matzkin, L. M., et al. (2008). Polytene Chromosomal Maps of 11 Drosophila species: The order of genomic scaffolds inferred from genetic and physical maps. Genetics. 179:1601-1655.
Matzkin, L. M. (2008). The molecular basis of host adaptation in cactophilic Drosophila: Molecular evolution of Glutathione-S-transferase (Gst) in Drosophila mojavensis. Genetics. 178:1073-1083.
Drosophila 12 Genomes Consortium (Matzkin, L. M. co-author). (2007). Evolution of genes and genomes on the Drosophila phylogeny. Nature. 450:203-218.
Matzkin, L. M., Watts, T. D., Bitler B. G., Machado, C. A. and Markow, T. A. (2006). Functional genomics of cactus host shifts in Drosophila mojavensis. Molecular Ecology. 15:4635-4643.