Michael A. Riehle
B.S. University of Wisconsin (1993) in Entomology/Biology
M.S. University of Wisconsin (1996) in Entomology
Ph.D. University of Georgia (2003) in Entomology
Mosquito borne diseases, such as malaria, filariasis, and dengue, kill millions of people every year. Unfortunately, the most common method of controlling these important pests, insecticides, is becoming less effective as mosquitoes develop resistance.
We are interested in developing new strategies for controlling mosquitoes and the diseases they transmit. Specifically, we are attempting to understand the basic molecular mechanisms regulating reproduction, immunity, and lifespan in the mosquito. With this information we hope to develop better methods of controlling mosquitoes and mosquito-borne diseases.
We are also interested in understanding the ecology of a potentially important vector of human disease in Southern Arizona, the yellow fever mosquito Aedes aegypti. This mosquito is an important vector of dengue and dengue hemorrhagic fever and represents a potential risk for Arizona in the future.
For more details on our current research projects please visit the Riehle Lab website.
Corby-Harris V., Drexler A., Watkins de Jong L., Antonova Y., Pakpour N., Ziegler R., Ramberg F., Lewis E.E., Brown J.M, Luckhart S., and Riehle M.A. (2010) Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopeheles stephensi mosquitoes. PLoS Pathogens 6(7): e1001003
Joy T. , Corby-Harris V., Johnson A., and Riehle M.A. (2010) The impact of larval and adult dietary restriction on lifespan and reproduction in the mosquito Aedes aegypti. Experimental Gerontology 45(9): 685-690
Arik A.J., Rasgon J.L., Quicke K.M., and Riehle M.A. (2009) Manipulating insulin signaling to enhance mosquito reproduction: A possible genetic drive mechanism? BMC Physiology 9.
Pri-Tal B., Brown J.M., and Riehle M.A. (2008) Identification and characterization of the catalytic subunit of phosphatidylinositol 3-kinase in the yellow fever mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology 38(10): 932-9.
Rodrigues F.G., De Carvalho T.X.T., Rocha B.C., Riehle M.A., Pimenta P.F.P., Jacobs-Lorena M., Alves de Brito C.F., and Moreira L.A. (2008) Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes towards Plasmodium gallinaceum. Insect Biochemistry and Molecular Biology 17(2): 175-83.
Luckhart S, and Riehle M.A. (2007) The insulin signaling cascade from nematodes to mammals: Insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Devevelopmental and Comparative Immunology 31(7): 647-56.
Riehle M.A., Moreira C.K., Lampe D., Lauzon C., and Jacobs-Lorena M. (2007) Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut. International Journal of Parasitology 37(6): 595-603.
Riehle M.A. & Brown J.M. (2007) Identification and characterization of six Phosphatase and Tensin Homolog (PTEN) splice variants from the mosquito Aedes aegypti. Insect Molecular Biology 16(3): 277-86.
Riehle M.A., Fan Y, Cao C, and Brown MR. (2006) Molecular cloning and tissue localization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti. Peptides. 27(11): 2547-60.